Why might synthetic dopamine become less effective over time?

Question by brianna: Why might synthetic dopamine become less effective over time?
I saw a movie about post-encephalitic parkinsonism (and I looked it up after to confirm the details), and apparently treatment with L-dopa (i.e. synthetic dopamine) was effective for a while but stopped working over time. In normal Parkinson’s patients it makes sense that treatment would become less effective as the disease progresses. However, in patients with post-encephalitic parkinsonism, the dopamine-producing cells where wiped out years ago by an infection that is long gone, so the damage shouldn’t be progressive. However, as far as I know the body doesn’t build up tolerance to dopamine, so if the condition is static, why should treatment with synthetic dopamine become less effective over time?

Best answer:

Answer by hmt42play
the function is simple but complex try the web site below for more info. “dopamine receptors from structure to function”

Give your answer to this question below!

Get the book now