Q&A: Why might synthetic dopamine become less effective over time?

Question by brianna: Why might synthetic dopamine become less effective over time?
I saw a movie about post-encephalitic parkinsonism (and I looked it up after to confirm the details), and apparently treatment with L-dopa (i.e. synthetic dopamine) was effective for a while but stopped working over time. In normal Parkinson’s patients it makes sense that treatment would become less effective as the disease progresses. However, in patients with post-encephalitic parkinsonism, the dopamine-producing cells where wiped out years ago by an infection that is long gone, so the damage shouldn’t be progressive. However, as far as I know the body doesn’t build up tolerance to dopamine, so if the condition is static, why should treatment with synthetic dopamine become less effective over time?

Best answer:

Answer by hmt42play
the function is simple but complex try the web site below for more info. “dopamine receptors from structure to function”

Add your own answer in the comments!